 | 2022-05-25 4:30 AM | NYG - Jordan Mosley (DB) | Undisclosed | [TSN] IR, undisclosed |
| 2022-05-24 1:30 PM | CAR - Marquis Haynes (DE) | Hand | [CBS] Questionable for Week 1 vs. Cleveland |
| 2022-05-24 1:00 PM | CIN - Alex Cappa (G) | Abdomen | [CBS] Questionable for Week 1 vs. Pittsburgh |
| 2022-05-24 12:30 PM | MIA - Tua Tagovailoa (QB) | Illness | [CBS] Questionable for Week 1 vs. New England |
| 2022-05-24 12:00 PM | BUF - Dawson Knox (TE) | Undisclosed | [CBS] Questionable for Week 1 at L.A. Rams |
| 2022-05-24 1:30 AM | NYJ - Rodney Adams (WR) | Illness | [CBS] Questionable for Week 1 vs. Baltimore |
| 2022-05-24 12:30 AM | PIT - Bryce Watts (DB) | Undisclosed | [CBS] Questionable for Week 1 at Cincinnati |
| 2022-05-24 12:30 AM | CHI - Ledarius Mack (DE) | Undisclosed | [CBS] Questionable for Week 1 vs. San Francisco |
| 2022-05-23 8:00 PM | LAR - Matthew Stafford (QB) | Elbow | [CBS] Questionable for Week 1 vs. Buffalo |
| 2022-05-23 7:00 PM | DEN - Jerry Jeudy (WR) | Back | [CBS] Questionable for Week 1 at Seattle |
| 2022-05-23 6:30 PM | SEA - Rashaad Penny (RB) | Hamstring | [CBS] Questionable for Week 1 vs. Denver |
| 2022-05-23 6:00 PM | LAS - Malkelm Morrison (DB) | Undisclosed | [CBS] Retired |
| 2022-05-23 5:00 PM | LAR - Matthew Stafford (QB) | Shoulder | [CBS] Questionable for Week 1 vs. Buffalo |
| 2022-05-22 3:30 AM | TB - Luke Goedeke (OT) | Undisclosed | [CBS] Out for Week 1 at Dallas |
| 2022-05-22 3:30 AM | CIN - Jeffrey Gunter (DE) | Undisclosed | [CBS] Questionable for Week 1 vs. Pittsburgh |
| 2022-05-21 12:00 PM | NYG - Kadarius Toney (WR) | Knee | [CBS] Questionable for Week 1 at Tennessee |
| 2022-05-20 1:30 PM | DET - Jameson Williams (WR) | Undisclosed | [USAToday] Williams is on the mend from surgery to repair a torn ACL, and it is uncertain if he will take on the Eagles in Week 1. |
| 2022-05-19 9:30 PM | TEN - Robert Woods (WR) | Undisclosed | [USAToday] Woods is on the mend from a torn ACL that ended his 2022 season. It is unclear if he will play Week 1 against the Giants. |
| 2022-05-19 4:00 PM | WAS - Tyler Larsen (C) | Heel | [CBS] Questionable for Week 1 vs. Jacksonville |
| 2022-05-19 4:00 PM | WAS - Chase Young (DE) | Knee | [CBS] Questionable for Week 1 vs. Jacksonville |