 | 2021-10-24 12:10 AM | CHI - Patrick Kane (RW) | Undisclosed | [TSN] IR, COVID-19 protocol |
| 2021-10-23 10:40 PM | VGK - Mark Stone (RW) | Lower Body | [CBS] IR. Expected to be out until at least Oct 24 |
| 2021-10-23 10:40 PM | MON - Joel Edmundson (D) | Undisclosed | [CBS] IR. Expected to be out until at least Nov 2 |
| 2021-10-23 8:40 PM | LAK - Drew Doughty (D) | Lower Body | [USA] questionable: Doughty was held out of the last contest with a lower-body injury, and it is undetermined if he will take part in Monday's matchup with the Blues.. |
| 2021-10-23 7:40 PM | TBL - Gemel Smith (C) | Lower Body | [USA] questionable: Smith has missed the last three games with a lower-body injury, and it is up in the air if he will play against the Sabres on Monday.. |
| 2021-10-23 7:40 PM | PHI - Ryan Ellis (D) | Undisclosed | [USA] questionable: Ellis sat out the last game with an undefined injury, and it is unknown if he will take on the Oilers on Wednesday.. |
| 2021-10-23 7:40 PM | NJD - Jonathan Bernier (G) | Lower Body | [USA] questionable: Bernier has sat out the last two contests due to a lower-body injury, and it remains to be seen he will face the Flames on Tuesday.. |
| 2021-10-23 7:40 PM | LAK - Drew Doughty (D) | Knee | [CBS] Expected to be out until at least Oct 25 |
| 2021-10-23 7:10 PM | LAK - Drew Doughty (D) | Lower Body | [CBS] Expected to be out until at least Oct 25 |
| 2021-10-23 6:10 PM | VGK - Zach Whitecloud (D) | Lower Body | [USA] out: Whitecloud is sidelined with a lower-body injury, and he will miss an extended period.. |
| 2021-10-23 5:40 PM | OTT - Matt Murray (G) | Head | [TSN] day-to-day, Head - left game |
| 2021-10-23 5:10 PM | OTT - Matt Murray (G) | Head | [NBC] Head - left game (day-to-day) |
| 2021-10-23 4:40 PM | OTT - Matt Murray (G) | Head | [USA] questionable: Murray sat out the last contest with a head injury, and it has yet to be established if he will suit up for Monday's clash with the Capitals.. |
| 2021-10-23 4:40 PM | NJD - Jonathan Bernier (G) | Lower Body | [CBS] Expected to be out until at least Oct 26 |
| 2021-10-23 4:40 PM | COL - Valeri Nichushkin (RW) | Upper Body | [CBS] IR. Expected to be out until at least Oct 26 |
| 2021-10-23 4:10 PM | VGK - Alec Martinez (D) | Lower Body | [CBS] Day-to-Day |
| 2021-10-23 4:10 PM | VGK - Zach Whitecloud (D) | Lower Body | [CBS] Expected to be out until at least Nov 2 |
| 2021-10-23 4:10 PM | OTT - Matt Murray (G) | Head | [CBS] Day-to-Day |
| 2021-10-23 3:40 PM | PIT - Kris Letang (D) | Undisclosed | [TSN] day-to-day, COVID-19 protocol |
| 2021-10-23 3:40 PM | PHI - Ryan Ellis (D) | Undisclosed | [TSN] day-to-day, Undisclosed injury |