 | 2021-09-20 1:40 PM | PHI - Samuel Morin (LW) | Undisclosed | [CBS] Questionable for start of season |
| 2021-09-20 12:10 PM | BOS - Charlie Coyle (C) | Knee | [CBS] Questionable for start of season |
| 2021-09-20 4:10 AM | EDM - Dmitri Samorukov (D) | Jaw | [USA] out: Samorukov has a broken jaw and is expected to miss at least six weeks of action.. |
| 2021-09-16 11:10 PM | VGK - Peyton Krebs (C) | Jaw | [CBS] Probable for start of season |
| 2021-09-16 10:40 PM | OTT - Thomas Chabot (D) | Upper Body | [CBS] Probable for start of season |
| 2021-09-16 10:40 PM | NYI - Anders Lee (LW) | Knee | [CBS] Probable for start of season |
| 2021-09-16 10:40 PM | MON - Shea Weber (D) | Ankle | [CBS] Expected to be out until at least Sep 1 |
| 2021-09-16 10:40 PM | EDM - Warren Foegele (LW) | Upper Body | [CBS] Probable for start of season |
| 2021-09-16 10:10 PM | BUF - Jack Eichel (C) | Neck | [CBS] Probable for start of season |
| 2021-09-16 10:10 PM | BOS - John Moore (D) | Hip | [CBS] Probable for start of season |
| 2021-09-16 4:40 PM | MIN - Kirill Kaprizov (LW) | Contract Dispute | [CBS] Questionable for start of season |
| 2021-09-15 1:40 PM | EDM - Dylan Holloway (LW) | Wrist | [USA] out: Holloway is recovering from offseason wrist surgery, and he is expected to miss at least three months of action.. |
| 2021-09-14 5:40 PM | BUF - Lukas Rousek (RW) | Knee | [USA] out: Rousek is sidelined after undergoing surgery to repair a torn ACL, and team officials have yet to provide an exact return date.. |
| 2021-09-13 5:40 PM | ANA - Ryan Kesler (F) | Hip | [CBS] Expected to be out until at least Sep 1 |
| 2021-09-09 4:10 AM | PIT - Sidney Crosby (C) | Upper Body | [FOX] Out Upper body |
| 2021-09-08 10:40 PM | PIT - Sidney Crosby (C) | Wrist | [USA] out: Crosby is recovering from wrist surgery, and he will remain sidelined until at least the end of October.. |
| 2021-09-08 7:10 PM | PIT - Sidney Crosby (C) | Wrist | [USA] out: Crosby is recovering from wrist surgery, and it remains to be seen when he will return to the lineup.. |
| 2021-09-08 5:40 PM | PIT - Sidney Crosby (C) | Wrist | [CBS] Expected to be out until at least Oct 23 |
| 2021-09-07 3:10 AM | CAR - Jake Gardiner (D) | Hip | [CBS] Expected to be out until at least Mar 1 |
| 2021-09-07 3:10 AM | BOS - Connor Clifton (D) | Covid-19 | [CBS] Questionable for start of season |